Two Cases of Invasive Aspergillus Sinusitis and Mastoiditis Successfully Treated with Voriconazole

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  • ボリコナゾールが著効した副鼻腔と中耳の侵襲性アスペルギルス症例
  • リンショウ ボリコナゾール ガ チョコウシタ フクビクウ ト チュウジ ノ シンシュウセイ アスペルギルス ショウレイ

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We report two cases of invasive aspergillosis of the head and neck regions. One patient was a 56-year-old male with invasive aspergillus sinusitis. The other patient was a 14-year-old boy with aspergillus mastoiditis after bone-marrow transplantation. Both cases were inoperable because of vascular invasion by aspergillus, and treatment with antifungal agents was discontinued due to severe side effects. A novel triazole voriconazole (VRCZ) was then used for salvage therapy and successfully treated invasive aspergillosis in both cases. VRCZ is an effective and well tolerated agent to treat invasive aspergillosis of the head and neck regions.

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