書誌事項
- タイトル別名
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- A Case of MTX-associated Lymphoproliferative Disorder
- 臨床 メトトレキサート関連リンパ増殖性疾患例
- リンショウ メトトレキサート カンレン リンパ ゾウショクセイ シッカンレイ
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抄録
Subjects with rheumatoid arthritis (RA) risk developing malignant lymphoproliferative disorder, although why remains controversial, immunosuppresive therapy—specifically low-dose methotrexate (MTX)- and Epstein-Barr virus infection are suspected of contributing to this risk. Widely used to treat RA, MTX has been suggested in several studies to increase malignant lymphoma risk. A 75-year-old man with RA and treated 9 years with MTX suffered right neck lymphoid node and tonsil swelling that eventually developed into an ulcer. Blood chemistry findings showed elevated lactic dehydrogenase (LDH) and soluble IL-2 receptor. Enhanced computed tomography (CT) confirmed bilateral neck lymph node and right-tonsil swelling.<br> Histopathologically, he was diagnosed with diffuse large B-cell lymphoma in neck lymph node biopsy with EBER-1. Clinically, he was diagnosed with MTX-associated lymphoproliferative disorder (MTX-LPD). MTX was discontinued 2 weeks after, his sore throat had disappeared, and CT 40 days later showed that all lesions also had disappeared. His clinical course continues to be good with no sign of recurrence.<br>
収録刊行物
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- 耳鼻咽喉科臨床
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耳鼻咽喉科臨床 104 (5), 371-377, 2011
耳鼻咽喉科臨床学会
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詳細情報 詳細情報について
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- CRID
- 1390001204264165760
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- NII論文ID
- 10027972689
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- NII書誌ID
- AN00107089
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- ISSN
- 18844545
- 00326313
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- NDL書誌ID
- 11102629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可