Heterotransplantation of a Human Hypopharyngeal Cancer in Nude Mice

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  • ヒト下いん頭がんのヌードマウスへの移植
  • ヒトカ イントウガン ノ ヌードマウス エ ノ イショク

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Using the method of heterotransplantation of human tumors in nude mice first performed by Rygaad and Povlsen, we have succeeded in transplanting hypopharyngeal cancer. No previous success in hypopharyngeal cancer transplantation has been reported. During nine successive transplants, we measured tumor growth rate and studied the changes histologically using light and electron microscopy.<br>The rate of growth and mutation increased sharply in the first three transplants. However, in the fifth to ninth transplants, we did not observe remarkable changes either in histology or growth rate. These results do not conform to the findings reported by Povlsen that the tumors maintained in nude mice retained the cytological and histological appearance of the inoculated human material.

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