書誌事項
- タイトル別名
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- Protective effects of LipoPGE1, prostaglandin E1 incorporated in lipid microspheres, against liver injury caused by ischemia-reperfusion.
- ラット カンゾウ ノ キョケツ サイ ジュンカン ショウガイ ニ タイスル リ
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Effect of LipoPGE1 on liver injury caused by ischemia-reperfusion were compared with that of PGE1-CD, cyclodextrin clathrated PGE1, in rats. LipoPGE1 (10μg/kg) and PGE1-CD (10μg/kg) were gradually injected into the portal vein 5 min both prior to ischemia and prior to reperfusion. In only the group receiving injections of vehicle alone, rats died within 2 days after the episode of 90-min liver ischemia. The survival rate of all rats treated with LipoPGE1 was higher than that of rats who received vehicle alone, which indicates that LipoPGE1 pretherapy improved the survival of rats after liver ischemia-reperfusion. LipoPGE1 markedly suppressed elevations of GOT, GPT, and LDH, lipid peroxide and aromatic amino acid levels in the plasma caused by ischemiareperfusion of the liver. When animals were given a single dose of LipoPGE1 prior to reperfusion, LipoPGE1 also suppressed elevations of GOT, GPT, LDH and lipid peroxide levels caused by 30min of liver ischemia followed by 12-hr reperfusion. These suppressive effects with LipoPGE1 were stronger than those of PGE1-CD. These findings suggest that LipoPGE1 may have therapeutic applications in the treatment of hepatic injury.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 105 (2), 77-86, 1995
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204270673408
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- NII論文ID
- 10006059783
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK2MXjsleis7c%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3606043
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- PubMed
- 7737595
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
