Roles of Endothelins in astrocytic responses to brain injuries.

DOI 8 References
  • KOYAMA Yutaka
    Department of Pharmacolo y, Faculty of Pharmaceutical Sciences, Osaka University
  • BABA Akemichi
    Department of Pharmacolo y, Faculty of Pharmaceutical Sciences, Osaka University

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Other Title
  • 脳傷害時のアストロサイトの機能変化におけるエンドセリンの役割

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Abstract

Endothelins, potent vasoconstricting peptides, have multiple actions on nonmuscle tissues. ETs present in brain and the ET contents increase on brain injuries, suggesting an involvement in path hysiological responses of the injured rain. Astrocytes have receptors for ET. However, significance of astrocytic ET receptors are unknown. On brain damages such as ischemia and head trauma, astroc rtes changes their phenotype to “reactive astrocytes”. Reactive astrocytes produce neurotro is factors and support synaptic regeneration after brain damages. In this study, effect of ET on induction of reactive astrocytes were examined by immunohistochemical staining for GFAP, a marker of reactive astrocytes. Injection of ET-3 (40pmole) into rat caudiate utamen increased GFAP positive cells. An ETB receptor agonist, Ala1, .3, 11, 15-ET-1 (40pmole), also increased GFAP positive astrocytes, while marked cell dams a was not induced. Applications of vasodilators, hydrarazine (20mg/Kg/day, i.p.) and ifenprodil (4mg/Kg/day, i.p.), did not prevent ET-induced increase in GFAP positive cells. These results suggest that ETs are involved in the generation of reactive astrocyte after brain injuries.

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Details 詳細情報について

  • CRID
    1390001204270776448
  • NII Article ID
    10008631413
  • NII Book ID
    AN00198335
  • DOI
    10.1254/fpj.106.supplement_167
  • ISSN
    13478397
    00155691
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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