新しい抗うつ薬Ｑｕｉｎｕｐｒａｍｉｎｅの脳波学的研究

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  • Electroencephalographic(EEG) effect of quinupramine in the rabbit.
  • アタラシイ コウウツヤク Quinupramine ノ ノウハガクテキ ケンキ

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Electroencephalographic (EEG) effect of quinupramine was investigated in unanesthetized rabbits with chronic electrode implants, and it was compared with those of imipramine and amitriptyline. Quinupramine (0.56 ?? 3.2 mg/kg) induced a marked drowsy pattern of spontaneous EEG: high voltage slow waves increased in the cortex, while the hippocampal theta rhythm was desynchronized. Imipramine (1.0 ?? 5.6 mg/kg) and amitriptyline (0.56 ?? 3.2 mg/kg) also elicited similar EEG effects. The EEG arousal response to auditory stimulation and to electric stimulation of the mesencephalic reticular formation, posterior hypothalamus and centromedian thalamus was markedly suppressed by quinupramine, imipramine and amitriptyline. The EEG arousal response induced by i.v. injection of physostigmine was markedly suppressed by quinupramine, amitriptyline and imipramine. Quinupramine showed no significant effect on the photic driving response and recruiting response. Quinupramine slightly enhanced the limbic afterdischarges elicited by either hippocampal or amygdaloid stimulation, while amitriptyline and imipramine caused an initial suppression followed by a quick recovery. The EEG effects of quinupramine were similar to those of amitriptyline in both qualitative and quantitative aspects.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 89 (6), 339-354, 1987

    公益社団法人 日本薬理学会

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