Effects of flutropium bromide, a new antiasthma drug, alone or in combination with salbutamol, aminophylline and disodium cromoglycate on the acetylcholine induced bronchoconstriction.
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- MIZUNO Hiroyuki
- Central Research Laboratory, SS Pharmaceutical Co., Ltd
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- TAKAHASHI Yoshinori
- Central Research Laboratory, SS Pharmaceutical Co., Ltd
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- OHNO Hiromitsu
- Central Research Laboratory, SS Pharmaceutical Co., Ltd
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- MISAWA Miwa
- Department of Applied Pharmacology, School of Pharmacy, Hoshi University
Bibliographic Information
- Other Title
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- アセチルコリン誘発気道収縮における新規抗ぜん息薬flutropium bromideとSalbutamol, aminophyllineおよびdisodium cromoglycateの併用効果
- アセチルコリン ユウハツ キドウ シュウシュク ニ オケル シンキ コウ ゼン
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Abstract
Effects of flutropium bromide, a new bronchodilator with an anticholinergic action, alone or in combination with other antiasthma drugs were investigated in guinea pigs by using an index of inhibition of the acetylcholine (ACh)-induced bronchoconstriction. Single inhalation of flutropium bromide (0.0003%) into the airways of guinea pigs inhibited the ACh (i.v.)-induced bronchoconstriction without changing the fall in blood pressure induced by ACh. When salbutamol (3 μg/kg, i.v.), aminophylline (5 mg/kg, i.v.) or disodium cromoglycate (10 mg/kg, i.v.) was administered in combination with flutropium bromide (0.0003%), bronchodilation was enhanced as compared with single administration of the respective antiasthma drugs. From the above results, it is indicated that inhalation of flutropium bromide provides a more efficient bronchodilation in combination with other antiasthma drugs that possess different mechanisms of antiasthma effects.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 95 (1), 31-40, 1990
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204270826240
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- NII Article ID
- 130000759097
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3263904
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- PubMed
- 1968028
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed