書誌事項
- タイトル別名
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- Quantitative assessment of gastric mucosal bleeding in the development of acute gastric mucosal lesions in the rat and prophylactic effect of elcatonin.
- イ シュッケツ レンゾク ソクテイ ニ ヨル ジッケンテキ キュウセイ イ ネ
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説明
Intraperitoneal injection of indomethacin (5, 10 and 20 mg/kg) caused acute gastric mucosal lesions in the conscious restrained rat and also hypersecretion of gastric acid. Cimetidine, an H2-receptor antagonist, was found to prevent gastric mucosal bleeding and acid secretion induced by indomethacin. Elcatonin at higher doses than 2.5 U/kg (0.5 μg/kg) was effective for protecting the gastric mucosa against indomethacin irritation, and it inhibited acid output in response to this ulcerogen. The acid inhibitory effect of elcatonin might be implicated in its cytoprotective action.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 95 (3), 113-119, 1990
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204271014528
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- NII論文ID
- 40003049924
- 10005708412
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXitFSrsrk%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3659433
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- PubMed
- 2354832
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可