Bibliographic Information
- Other Title
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- ラットのアレルギー性足浮腫反応に対するKP‐136の作用
- ラット ノ アレルギーセイ ソクフシュ ハンノウ ニ タイスル KP-136
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Abstract
The pharmacological properties of KP-136, an inhibitor of type I allergy, were studied in rat paw models. In four allergic responses, three of the immediate type and one delayed type, KP-136 (p.o.) produced potent inhibitions on the mast cell-mediated type I allergy (ID30 : 1.0 mg/kg) and the neutrophil-infiltrated passive Arthus reaction (ID30 : 1.6 mg/kg). In addition, KP-136 (10 mg/kg, 50 mg/kg, p.o.) inhibited the injury of bone tissues in rat adjuvant arthritis, confirming that it was effective on the allergic inflammation with tissue injury. Although KP-136 was a weak inhibitor of carrageenin-induced paw edema, prostaglandin synthesis and complement-mediated hemolysis, the compound inhibited the release of lysosomal enzymes such as lysozyme and β-glucronidase in the passive Arthus reaction, suggesting the blockage of inflammatory mediator release for its mode of action.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 95 (3), 83-90, 1990
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271015936
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- NII Article ID
- 40003049928
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXitFSksL0%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3659488
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- PubMed
- 2141318
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed