Effects of Sodium Taurine N-carbodithioate (TDT) on the NADH-cytochrome c reductase and ATPase activities in liver cell membranes of rats treated with C Cl<SUB>4</SUB>
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- MASUDA Yasusuke
- Department of Pharmacology, Wakayama Medical College
Bibliographic Information
- Other Title
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- 四塩化炭素(CCl<SUB>4</SUB>)障害白鼠に於ける肝細胞膜機能に及ぼすSodium Taurine N-carbodithioate (TDT)の影響
- 4エンカ タンソ CCl4 ショウガイ シロネズミ ニ オケル キモ サイボウマク キノウ ニ オヨボス Sodium Taurine N-carbodithioate TDT ノ エイキョウ
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Description
The influence of TDT administration in vivo on the changes of two enzymic activities in the liver cell membranes damaged by C Cl4 was observed. The following results were obtained. 1) In normal rats, TDT had no significant effect on NADH-cytochrome c reductase and ATPase activities in membranes or microsomes. 2) TDT was capable of preventing not only the changes of NADH-cytochrome c reductase and ATPase activities in cell membranes produced by C Cl4 administration, but also the leakage of NADH-cytochrome c reductase into plasma. 3) TDT did not modify the body temperature in normal rats and that induced by C Cl4, neither. 4) The mechanism of action of TDT was discussed.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 66 (1), 11-18, 1970
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271043072
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- NII Article ID
- 130000757354
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE3MXktVeksrc%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 8404038
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- PubMed
- 4246818
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed