Efficacy Evaluation of TBPM-PI, an Oral Carbapenem Antibacterial Agent, in Children with Acute Otitis Media Including Recurrent/Persistent Cases

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  • 反復・遷延例を含む小児急性中耳炎に対する経口カルバペネム系抗菌薬TBPM-PIの有効性評価
  • ヤクブツ ハンプク ・ センエンレイ オ フクム ショウニ キュウセイ チュウジエン ニ タイスル ケイコウ カルバペネムケイ コウキンヤク TBPM-PI ノ ユウコウセイ ヒョウカ

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Abstract

In recent years, the increasing incidence of drug-resistant strains such as penicillin-resistant Streptococcus pneumoniae (PRSP) and β-lactamase-non-producing ampicillin-resistant Haemophilus influenzae (BLNAR) have been identified as causative pathogens in acute otitis media (AOM) and this fact is considered to be an important cause of intractable cases. In the present study, we evaluated the efficacy of tebipenem-pivoxil (TBPM-PI) in moderate to severe AOM cases including recurrent/persistent cases and discussed the clinical positioning of TBPM-PI. Ninety-six cases of AOM in childhood (65 simple acute cases and 31 recurrent/persistent cases) were evaluated. The incidence of recurrent/persistent cases was significantly high in the under 2-year-old age group (p=0.0426). S. pneumoniae and H. influenzae were isolated as the major causative pathogens; specifically, S. pneumoniae was isolated in 63% of the uncomplicated acute cases, H. influenzae was isolated in 71% of the recurrent/persistent cases, and resistant strains were isolated at a high rate for both of the bacterial species. TBPM-PI showed favorable antibacterial activities against these isolated pathoegns. Regarding the curative effect, the cure rate determined by the primary physicians was as high as 90% in the moderate to severe cases including recurrent/persistent cases and the cases resistant to prior therapy. This result suggested that TBPM-PI is useful in children with AOM, especially in recurrent/persistent cases and cases resistant to prior therapy.<br>

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