Anxiety and Stress. Multiplicity of anxiety and serotonin nervous system.
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- TSUJI Minoru
- Department of Pharmacology and Intractable Disease Research Center (Division of Drug Research and Development)
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- TAKEDA Hiroshi
- Department of Pharmacology and Intractable Disease Research Center (Division of Drug Research and Development)
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- MATSUMIYA Teruhiko
- Department of Pharmacology and Intractable Disease Research Center (Division of Drug Research and Development)
Bibliographic Information
- Other Title
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- 不安とストレス 不安の多様性とセロトニン神経系
- フアン ト ストレス
- 不安とストレス
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Abstract
It has been recently suggested that the central serotonin (5-HT) nervous system may be involved in the modulation of anxiety. Especially, the possible importance of 5-HT1A receptors in anxiety was raised by evidence that the anxiolytic properties of 5-HT1A-receptor agonists have now been confirmed in clinical studies. On the other hand, in preclinical studies using various animal models of anxiety, these novel agents tend to have weak and/or variable effects in some paradigms used to detect the anxiolytic activities of benzodiazepines. These differential patterns of drug effects within various models promote the concept of “multiplicity of anxiety”. Recently, a new experimental model called the T-maze was developed in attempts to analyze a different type of anxiety; i.e., conditioned fear and unconditioned fear response. The results of a series of behavioral studies using the T-maze test suggest that distinct 5-HT pathways may modulate the different classes of anxiety. In our recent studies using the hole-board test, apparent differential behavioral effects between benzodiazepine anxiolytics and 5-HT1A agonists on emotionality of stressed mice were also observed. These results suggest that benzodiazepine or 5-HT1A receptors may play a different role in modulating emotionality. These studies may provide new information to investigate the pathophysiological characteristics of various types of anxiety disorders and to develop novel therapeutic agents.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 115 (1), 29-38, 2000
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204271228800
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- NII Article ID
- 10005705332
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DC%2BD3cXhs1artg%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 4954059
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- PubMed
- 10876813
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed