メチル　Ｏ‐（４‐ヒドロキシ‐３‐メトキシシンナモイル）レセルピン（ＣＤ‐３４００）およびレセルピン誘導体投与ラットの胃粘膜所見および胃酸分泌動態

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  • Findings in gastric mucosa and gastric secretion of methyl O-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400) and reserpine derivatives administered subcutaneously to rats.
  • Methyl 0 4 hydroxy 3 methoxycinnamoyl r

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CD-3400 developed by Nippon Chemiphar Co. Ltd., is a new antihypertensive agent belonging to the class of rauwolfia alkaloids. Influence of the agent on gastric mucosa, healing process of acetic acid-induced gastric ulcer and gastric juice in rats was investigated and compared with effects of reserpine and rescinnamine. CD-3400-induced gastric lesions were fewer in number than those produced with reserpine and rescinnamine in fasted rats. After a three day treatment of CD-3400 to fed rats, however, there were few gastric lesions, while reserpine and rescinnamine-induced gastric lesions were aggravated to a greater extent than when a single administration was given to fasted rats. Influence of CD-3400, reserpine and rescinnamine on the healing process of acetic acid-induced ulcer was insignificant, but treatment with high doses of reserpine and rescinnamine resulted in death. Pretreatment with CD-3400 and reserpine produced a decrease in gastric acid and K+, and an increase in Na+. Repeated administration of reserpine for 5 days resulted in a decrease of both gastric volume and acid, while such was not seen with CD-3400. Treatment with anticholinergic agents such as atropine sulfate and atropine methylbromide inhibited CD-3400 and reserpine-induced gastric lesions. From these results, it would appear that cholinergic factors play a role in the pathogenesis of CD-3400-induced gastric lesions, as is the case with reserpine, and that the responses of these lesions to reserpine and CD-3400 correlate with changes of ionic fluxes in gastric juice.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (8), 969-978, 1976

    公益社団法人 日本薬理学会

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