Effects of terguride, an regot alkaloid derivative, on the central nervous system: Biochemical and behavioral studies.
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- IKOMA Yukihiro
- Research Department, Nihon Schering K.K
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- AKAI Tetsuo
- Research Department, Nihon Schering K.K
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- NAKATA Yukie
- Research Department, Nihon Schering K.K
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- HARA Kimio
- Research Department, Nihon Schering K.K
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- WACHTEL Helmut
- Research Laboratories, Schering AG, Berlin
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- YAMAGUCHI Motonori
- Research Department, Nihon Schering K.K
Bibliographic Information
- Other Title
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- 麦角アルカロイド誘導体テルグリドの中枢神経系への影響: 生化学的及び行動薬理学的検討
- バッカク アルカロイド ユウドウタイ テルグリド ノ チュウスウ シンケイケイ
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Abstract
Effects of terguride, a 9, 10-dihydrogenated derivative of lisuride, on the central nervous system were investigated in rodents in comparison with those of lisuride. In vitro binding studies in rat brains showed that terguride, similar to lisuride, had a high affinity for D2-, 5-HT 1A-, 5-HT 2-, α1- and α2- receptors. Terguride, as does lisuride, induced hypomotility and yawning at low doses in rats, suggesting its presynaptic D2-agonist action. Terguride, unlike the postsynaptic D2-agonist lisuride, induced neither hypermotility nor stereotypy in rats and guinea pigs, but suppressed the hypermotility and stereotypy induced by apomorphine. Terguride suppressed haloperidol-induced catalepsy in rats and induced contralateral rotations in unilaterally 6-0HDA-lesioned rats, as does lisuride. These effects may be due to the postsynaptic D2 partial agonist action. Terguride, unlike lisuride, neither induced the serotonin syndrome nor generalized to the discriminative stimuli of the 5-HT1A-agonist 8-OH-DPAT in rats. Terguride did not induce head twitch in mice. Terguride blocked noradrenaline-induced lethality and clonidine-induced hypothermia at high doses in mice. Repeated ad-ministration of terguride did not affect the behavioral actions in rats. Thus, the effects of terguride on the central nervous system seems to be produced by mediation of the agonist and partial agonist actions at presynaptic and postsynaptic D2- receptors, respectively.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 102 (2), 113-129, 1993
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271295360
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- NII Article ID
- 130001504790
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3sXlslCjsLw%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3844445
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- PubMed
- 8370555
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed