Heat shock protein 27 in osteoblasts.

DOI Web Site PubMed 72 References
  • KOZAWA Osamu
    Department of Pharmacology, Gifu University School of Medicine
  • TOKUDA Haruhiko
    Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences

Bibliographic Information

Other Title
  • 骨代謝とストレスタンパク質２７（ｈｅａｔ　ｓｈｏｃｋ　ｐｒｏｔｅｉｎ２７：ＨＳＰ２７）
  • コツ タイシャ ト ストレスタンパクシツ 27 heat shock protein 27 HSP27

Search this article

Abstract

Physiological stresses such as heat stress, chemical stress and mechanical stress induce the expression of heat shock protein (HSP) families in cells, which affects cell function. In the present review, we describe HSP27, a small HSP in osteoblasts, especially the regulatory mechanism of the induction of HSP27 stimulated by physiological bone agents. Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC). On the contrary, physiological regulators of bone such as endothelin-1, prostaglandin F2α (PGF2α), PGD2, and basic fibroblast growth factor (bFGF) induce HSP27 via protein kinase C (PKC) activation. In addition, the mitogen-activated protein (MAP) kinase superfamily takes part in the HSP27 induction. Thus, not only stress but also physiological agonists induce HSP27 in osteoblasts, and PKC or MAP kinases play important roles in the induction of HSP27.<br>

Journal

References(72)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top