On the urea alteration in the α-receptor and the acetylcholine receptor of the vas deferens

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  • KUBOTA Kazuhiko
    Faculty of Pharmaceutical Sciences, Science University of Tokyo Summary
  • SEKIDO Shozaburo
    Faculty of Pharmaceutical Sciences, Science University of Tokyo Summary

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  • 輸精管のα受容体およびAcetylcholine受容体の尿素変性について
  • ユセイカン ノ アルファ ジュヨウタイ オヨビ Acetylcholine ジュヨウタイ ノ ニョウソ ヘンセイ ニ ツイテ

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Abstract

Vas deferens of a guinea pig and a rat were treated with urea to investigate the chemical properties of their α and acetylcholine receptors. The urea treatment of the guinea pig vas deferens (2.0 M, 20 min) produced a slight depression in the response to KCl, but significant depressions in the response to noradrenaline and acetylcholine. In this case, the response to acetylcholine were depressed more profoundly than the response to noradrenaline, and the difference between both response was significant statistically.<BR> In the rat vas deferens, urea treatment (2.0 or 2.2 M, 20 min) scarcely produced the depression of the KCl response but caused a severe depression of the noradrenaline response.<BR> These results indicate that the acetylcholine receptor may be denaturated by urea more easily than the α-receptor.<BR> Both the heating and the urea treatment prevented selectively the functions of α-receptor and acetylcholine receptor without preventing the function of the smooth muscle cell membrane, so that it is suggested that both α and acetylcholine receptors are sensitive to the protein denaturation and are seemed to be composed of protein.

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