書誌事項
- タイトル別名
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- Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs.
- ヒンニョウ カイゼンザイ Propiverine hydrochloride
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説明
The effect of propiverine hydrochloride (P-4) on the function of the bladder in decerebrated dogs was compared with that of propantheline, an anticholinergic drug which is used for the treatment of micturitional disorders. P-4 (5 and 10 mg/kg, i.v.) significantly increased maximum vesical volume (Vmax) ; and at the dose of 10 mg/kg, i.v., it also significantly increased effective vesical volume (EV) when determined by cystometry. However, at the dose level of 2, 5 and 10 mg/kg, i.v., P-4 had no effect on residual volume (RV) after micturition contraction. Propantheline (0.25 and 0.5 mg/kg, i.v.) also significantly increased Vmax, but showed no effect on EV. At doses higher than 0.016 mg/kg, i.v., propantheline significantly. increased RV. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 95 (2), 55-61, 1990
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204271577984
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- NII論文ID
- 130000759101
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXit12ntLc%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3659472
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- PubMed
- 2328930
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可