イソプレニルフラボノイド系抗かいよう物質に関する基礎的研究　Ｉ　　広豆根成分イソプレニルカルコンの抗かいよう活性

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タイトル別名
  • Studies on the anti-ulcer effects of isoprenyl flavonoids(1)
  • イソプレニル フラボノイドケイ コウ カイヨウ ブッシツ ニ カンスル キソテ
  • The anti-ulcer effects of isoprenyl chalcone extracted from sophora subprostrata
  • 第1報広豆根成分イソプレニルカルコンの抗潰瘍活性

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抄録

A series of extracted fractions from sophora subprostrata was screened by determining anti-ulcer effects in pylorus ligated and stressed rats. Fr. [C-2] had the most potent anti-ulcer effects of all fractions extracted. Sophoradin and sophoranone which were isolated from Fr. [C-2] were also found to have inhibitory effects on ulcer formation in pylorus ligated and stressed rats. The anti-ulcer effect of sophoradin was relatively potent in comparison with that of sophoranone and/or Fr.[C-2].The anti-ulcer effect of sophoranone was approximately the same as that of Fr.[C-2].The authors examined the effects of sophoradin and sophoranone on gastric secretion in pylorus ligated rats. Sophoradin and sophoranone significantly reduced the volume of gastric juice. Sophoradin but not sophoranone inhibited the free and total acid output of gastric juice. The effect of sophoradin was examined on various secretagogues which induced gastric secretions in rats with acute fistula. Sophoradin showed a tendency to inhibit tetragastrin and insulin-induced gastric acid secretion, but there were no effects on methacholine and histamine-induced secretions. These results suggest that sophoradin may have marked anti-ulcer and inhibitory effects on gastric secretion.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 74 (8), 897-905, 1978

    公益社団法人 日本薬理学会

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