Pharmacological studies of penfluridol (II). The general pharmacological properties

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  • 抗精神病薬ペンフリドールの薬理学的研究　ＩＩ　　一般薬理作用
  • コウ セイシンビョウヤク Penfluridol ノ ヤクリガクテキ ケンキュ

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Abstract

General pharmacological properties of penfluridol (TLP-607), a long-acting antipsychotic drug, were examined in experimental animals and the following results were obtained. 1) TLP-607 produced a lowering of arterial blood pressure and bradycardia but had almost no effect on respiration and peripheral blood flow, 2) TLP-607 slightly inhibited hypertension induced by dopamine, adrenaline and noradrenaline, but had no effect on hypotension induced by acetylcholine and histamine. 3) Antagonistic actions of TLP-607 on such spasmogens as acetylcholine, histamine and barium chloride were slightly stronger than those of haloperidol and chlorpromazine. 4) TLP-607 had neither ganglionic nor neuromuscular blocking action. 5) TLP-607 had a slight or no effect in the following experiments; protection against stomach ulcer, activity of ileum and uterus in vivo and in vitro, urinary volume and electrolytes excretion, and gastro-intestinal propulsion. These results suggest that TLP-607 has no striking peripheral actions in experimental animals.

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