Effect of a novel antiulcer drug, lafutidine, on experimental chronic gastritis in rats.
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- ONODERA Sadayoshi
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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- TANAKA Masato
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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- INABA Niro
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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- SUZUKI Takao
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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- SHIBATA Masahiro
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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- YAMAURA Tetsuaki
- Pharmaceuticals Research Laboratories, Fujirebio, Inc.
Bibliographic Information
- Other Title
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- 新規抗潰よう薬,ラフチジンのラットにおける実験的慢性胃炎モデルに対する作用
- シンキ コウ カイヨウヤク ラフチジン ノ ラット ニ オケル ジッケンテキ
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Abstract
Oral administration of an ammonia solution (0.01 %) or a sodium taurocholate solution (TCA solution, 5 mM) as drinking water for 4 weeks or 13 weeks, respectively, resulted in gastric mucosal thinning and decreased parietal cell numbers. Oral administration of TCA solution also caused cell infiltration in the lamina propria of the mucosa and mucosal fibrosis. When lafutidine (3, 10 mg/kg) was administered orally once daily for one week after the withdrawal of ammonia or TCA solution, the recovery of the mucosal thickness in the fundic gland area and the parietal cell number were significantly accelerated, and the recovery of mucosal thickness in the pyloric gland area also tended to be accelerated. Lafutidine at 10 mg/kg for 1 week had no influence on normal mucosal thickness and parietal cell numbers. At the doses that produce equal or greater acid antisecretory effect than lafutidine, oral administration of cimetidine (30 mg/kg) and famotidine (1 mg/kg) had no effect on either of these atrophy indexes. These results demonstrate that lafutidine, unlike cimetidine and famotidine, can accelerate the healing of mucosal injuries in ammonia- and TCA-induced chronic gastritis models.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 109 (1), 31-40, 1997
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271966848
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- NII Article ID
- 10004946857
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaK2sXjtlGiuw%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 4108027
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- PubMed
- 9067997
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed