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- MIYAZAWA Tomoaki
- Biological Research Group, Nihon Schering K.K.
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- MURAYAMA Chie
- Biological Research Group, Nihon Schering K.K.
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- NAKAGAWA Hidehiko
- Biological Research Group, Nihon Schering K.K.
Bibliographic Information
- Other Title
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- 異型化赤血球誘発ラット脳梗塞に対するLisurideの影響
- イケイカ セッケッキュウ ユウハツ ラット ノウ コウソク ニ タイスル Li
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Abstract
Lisuride is an ergot derivative with central dopaminergic (D2 agonistic) and serotonergic (5-HT1A agonistic) activity. The effect of lisuride on experimental cerebral infarction in rats was investigated. Cerebral infarction was induced by intracarotid infusion of a 50-μl mixture in which deformed and rigid red blood cells treated with hypertonic solution were contained. Lisuride or 0.9 % NaCl was administered subcutaneously 30 min before induction of cerebral infarction. Lisuride (0.01 mg/kg) not only prolonged the survival time of the animals but also suppressed cerebral edema, increase in the electrolytes content and histological damage in the brain. These results suggest that lisuride has a protective effect against cerebral infarction.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 98 (6), 449-456, 1991
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204272139392
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- NII Article ID
- 130000758818
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3750343
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- PubMed
- 1783326
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed