Effect of cysteine ethylester hydrochloride (Cystanin®) on host defense mechanisms

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  • Ｃｙｓｔｅｉｎｅ　ｅｔｈｙｌｅｓｔｅｒ　ｈｙｄｒｏｃｈｌｏｒｉｄｅ（Ｃｙｓｔａｎｉｎ｀Ｒ´）の生体防御機構に及ぼす影響
  • Cysteine ethylester hydrochloride Cysta

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Abstract

Cysteine ethylester (10 ?? 100 mg/kg, p.o.) augmented the production of hemolytic plaque-forming cells (HPFC) to sheep red blood cells and lipopolysaccharide in the spleen of mice. It showed no effect, however, on the HPFC production to trinitrophenylated polyvinylpyrrolidone; and it had no activity as a polyclonal B cell activator like lipopolysaccharide. Cysteine ethylester at a concentration of 3 μM or more potentiated the phagocytosis of yeast by the peritoneal polymorphonuclear leukocytes of rats. This activity was less potent than that of levemisole and D-penicillamine. It also potentiated the reduction of nitroblue tetrazolium (NBT) by blood leukocytes prepared from guinea pigs and a human being. This activity was more potent than that of levamisole and D-penicillamine. Furthermore, cysteine ethylester at doses showing an immunopotentiating activity protected irradiated mice from death by spontaneous infection. These findings suggest that this drug may have a capacity to potentiate the host defense mechanisms.

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