書誌事項
- タイトル別名
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- Effect of cysteine ethylester hydrochloride (Cystanin®) on host defense mechanisms
- Cysteine ethylester hydrochloride Cysta
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説明
Cysteine ethylester (10 ?? 100 mg/kg, p.o.) augmented the production of hemolytic plaque-forming cells (HPFC) to sheep red blood cells and lipopolysaccharide in the spleen of mice. It showed no effect, however, on the HPFC production to trinitrophenylated polyvinylpyrrolidone; and it had no activity as a polyclonal B cell activator like lipopolysaccharide. Cysteine ethylester at a concentration of 3 μM or more potentiated the phagocytosis of yeast by the peritoneal polymorphonuclear leukocytes of rats. This activity was less potent than that of levemisole and D-penicillamine. It also potentiated the reduction of nitroblue tetrazolium (NBT) by blood leukocytes prepared from guinea pigs and a human being. This activity was more potent than that of levamisole and D-penicillamine. Furthermore, cysteine ethylester at doses showing an immunopotentiating activity protected irradiated mice from death by spontaneous infection. These findings suggest that this drug may have a capacity to potentiate the host defense mechanisms.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 82 (1), 27-35, 1983
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204272147456
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- NII論文ID
- 130000760576
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaL3sXkvFyqtLo%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 2636453
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- PubMed
- 6352429
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可