ＤＯＣＡ‐ｓａｌｉｎｅ高血圧ラットの血圧および尿量尿中Ｎａ，Ｋ排せつ量に対する数種βしゃ断薬およびサイアザイド利尿薬Ｐｅｎｆｌｕｚｉｄｅの作用

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タイトル別名
  • Effects of several β-blockers and a thiazide diuretic on the blood pressure, urinary water output and excretion of Na and K in DOCA-saline hypertensive rats
  • DOCA saline コウケツアツ ラット ノ ケツアツ オヨビ ニョウリョ

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Effects of β-blockers on the blood pressure (BP), urinary output (V) and excretion of Na+ (UNaV) and K+ (UKV) were studied in DOCA-saline hypertensive rats in comparison with those of a thiazide diuretic drug, penfluzide. Pindolol produced a hypotension at all infusion rates of Ringer's solution used and a decrease in V with a retention of Na+ and K+ at a low infusion rate. There was a parallel shift of Guyton's renal function curve back to the lower pressure ranges. Similar effects were observed with labetalol. Propranolol induced an increase in UKV at all infusion rates and had a diuretic action at a high infusion rate without producing a significant fall of BP. UKV tended to be increased after atenolol, with essentially no change in other parameters. A new β-blocker with α-blocking action, K-351, produced a hypotension at intermediate and high infusion rates and an increase in UNaV (low infusion rate) and UKV (low and high rates). UKV tended to be increased with another new β-blocker, N-696, with a fall of BP at high infusion rate. Penfluzide produced a significant decrease in BP at intermediate and high infusion rates and an increase in UKV at all infusion rates.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 82 (3), 181-190, 1983

    公益社団法人 日本薬理学会

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