視床内側核単一ノイロン活動に対するカプサイシンの作用

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  • Effects of capsaicin on spontaneous unit discharges in medial thalamic single neurons of cats.
  • シショウ ナイソクカク タンイツ ニューロン カツドウ ニ タイスル Caps

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The effect of capsaicin was studied in gallamine triethiodide immobilized adult cats. Single neurons were recorded from the medial thalamus with a stainless steel microelectrode. Out of 21 neurons recorded in this experiment, 10 were responsive to both nociceptive (pinch) and non-nociceptive (hair bending and/or tapping) stimuli. Six neurons were responsive to only non-nociceptive stimuli and 5 were not responsive to these stimuli. Out of 10 neurons responding to both nociceptive and non-nociceptive stimuli, 9 were responsive to both bradykinin (3 μg) and capsaicin (3 μg). Out of 6 neurons responding to only non-nociceptive sitmuli, 5 were not responsive to either bradykinin and capsaicin. All neurons responding to bradykinin were also responsive to capsaicin. The latency for bradykinin and capsaicin was 7.64±1.12 sec and 0.97±0.07 sec, respectively. The increase in firing frequency produced by capsaicin was depressed by morphine. However, these depressant effects of morphine on single unit activity were antagonized by naloxone.

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  • 日本薬理学雑誌

    日本薬理学雑誌 73 (8), 955-959, 1977

    公益社団法人 日本薬理学会

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