ＰＣＢ連続投与のラットに及ぼす影響と投与中止後の回復

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タイトル別名
  • Recovery from toxicological and biochemical effects of rats intoxicated with polychlorinated biphenyls.
  • PCB レンゾク トウヨ ノ ラット ニ オヨボス エイキョウ ト トウヨ チ

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Kanechlor-500 (KC-500, a polychlorinated biphenyl mixture containing 55% chlorine) was administered to rats at a dose level of 1, 10 and 100 mg/kg, twice a week for 15 weeks. At 15 weeks, the rats were sacrificed to determine toxicological effects and to analyze polychlorinated biphenyl (PCB) residues in tissues. In other groups, rats were sacrificed 15 weeks after discontinuation of the treatment. During the administration period, the enhancing effect of liver microsomal drug-metabolizing enzymes by KC-500 was more evident than the hematological and serum biochemical alterations. Histopathology of the liver included degeneration of liver cells, single cell necrosis, and lipofuscin accumulation in cytoplasma, and such was dose dependent. After cessation of the KC-500 treatment, several parameters reverted toward control values particularly in animals given lower doses. The order of the PCB levels in tissues analyzed by gas-chromatography was adipose tissue >> liver >> kidney> blood. Following a recovery period of 15 weeks the residue levels in adipose tissue and liver were 40 ?? 60% and 50 ?? 60% of those observed after 15 weeks treatment period to KC-500, respectively. Furthermore, storage levels of PCB in adipose tissue decreased more rapidly following discontinuation of administration of the low dose levels as compared to those given the highest dose. From the findings in the gas-chromatographic analyses, it is likely that some of the components are metabolized more rapidly than others when the activity of liver microsomal drug-metabolizing enzymes is enhanced by KC-500 itself.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 73 (8), 887-894, 1977

    公益社団法人 日本薬理学会

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