書誌事項
- タイトル別名
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- Stress and Redox Regulation. Cell injury and its protection in astrocytes.
- グリア サイボウ ノ ショウガイ ト ホゴ
- ストレスと細胞応答
この論文をさがす
抄録
Incubation of cultured astrocytes in Ca2+-containing medium after exposure to Ca2+-free medium causes Ca2+ influx followed by delayed cell death. Here, we summarize the mechanisms underlying the Ca2+-mediated injury of cultured astrocytes and the protective effects of drugs against Ca2+-reperfusion injury. Our results show that Ca2+-reperfusion injury of astrocytes appears to be mediated by apoptosis as evidenced by DNA fragmentation and nuclear condensation. Calpain, reactive oxygen species (ROS) production, calcineurin, caspase-3, and NF-κB activation are involved in Ca 2+-reperfusion injury. Several drugs including T-588 and idebenone protect astrocytes against Ca2+-reperfusion injury. The protective effect of idebenone is mediated by nerve growth factor production, whereas that of T-588 is mediated mainly by the mitogen-activated protein/extracellular signal-regulated kinase signal cascade.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 114 (5), 281-286, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204272385536
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- NII論文ID
- 10008182277
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK1MXntFansr8%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 4887313
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- PubMed
- 10621941
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可