A Case of Granular Cell Tumor of the Hypopharynx

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  • 下咽頭に発生した顆粒細胞腫例
  • 臨床 下咽頭に発生した顆粒細胞腫例
  • リンショウ シタ イントウ ニ ハッセイ シタ カリュウ サイボウ シュレイ

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<p>Granular cell tumor (GCT), also known as Abrikossoff tumor, is known as a benign, slow-growing neoplasm. While GCT can arise anywhere in the body, these tumors in the head and neck region, especially involving the tongue, account for 30%–50% of all cases. On the other hand, to the best of our knowledge, hypopharyngeal lesions are extremely rare, with only 11 case reports published in the literature.</p><p>Herein, we report a case of benign GCT arising from the hypopharynx in a 30-year-old female patient. The lesion in the hypopharynx was excised by microlaryngoscopic surgery. Histopathology of the resected lesion revealed features consistent with the diagnosis of GCT. Positive results of immunohistochemical staining for 100 protein and neuron-specific enolase (NSE) were helpful for making the correct diagnosis. The postoperative course was uneventful. The patient was asymptomatic without any evidence of recurrence postoperative observation.</p><p>GCT is a solitary submucosal tumor, however, in about 4%-16% of cases, multiple lesions are found. To detect multiple lesions, especially esophageal lesion, upper gastrointestinal endoscopy should be performed. Several reports have mentioned the possibility of misdiagnosing pseudoepitheliomatous hyperplasia of the overlying mucosa of a GCA as SCC. To prevent misdiagnosis, it is important to consider clinical findings, not only pathological diagnosis.</p>

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