Changes in pentobarbital hypnosis and hepatic metabolism in streptozotocin-diabetic mice.
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- FUJII Emiko
- Department of Pharmacology, Tokyo Women's Medical College
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- TSUKAHARA Fujiko
- Department of Pharmacology, Tokyo Women's Medical College
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- NOMOTO Teruko
- Department of Pharmacology, Tokyo Women's Medical College
Bibliographic Information
- Other Title
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- Streptozotocin糖尿マウスにおけるPentobarbitalの催眠作用と肝における代謝の変化について
- Streptozotocin トウニョウ マウス ニ オケル Pentobar
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Abstract
The present study deals with the hypnotic effect of pentobarbital (Pento) in relation to its metabolism in hepatic microsomes in streptozotocin (STZ, 170 mg/kg, i.p.) injected mice. Liver weight (mg/10 g body wt.) of STZ-treated mice was larger than that of the controls throughout the experimental period. Although the shortening of sleeping time induced by Pento (60 mg/kg, i.p.) was always observed, Pento-metabolizing enzyme activity (by the method of Kato et al., 1964) increased in mice with diabetes for 2 and 4 weeks but decreased in mice with diabetes for 8 weeks. Induction following phenobarbital (100 mg/kg, s.c.) and inhibition by SKF 525-A (10 mg/kg, i.p.) of hepatic metabolizing enzyme were found in both control and mice with diabetes for 2, 4 and 8 weeks, but these were not definitely correlated to their hepatic Pento-metabolizing enzyme activities. STZ-induced hyperglycemia and shortening of sleeping time by Pento were completely prevented by the pretreatment with nicotinamide (500 mg/kg, i.p.). NPH-insulin injection partially decreased hyperglycemia in STZ-diabetic mice, but sleeping time by Pento was not significantly affected. These results suggest that the hyposensitivity to Pento in STZ-diabetic mice is partially related to an abnormality of metabolism in liver such as the hyperglycemic state.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 90 (2), 83-89, 1987
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204272776576
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- NII Article ID
- 130000759456
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3148329
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- PubMed
- 2960599
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed