ＴＪ‐８００７の薬理学的研究　（第２報）　　虚血性脳障害保護作用

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • Pharmacological study of TJ-8007 (Tsumura-Zokumeito). (II): Protective effect of TJ-8007 against cerebral ischemia.
  • TJ-8007 ノ ヤクリガクテキ ケンキュウ 2 キョケツセイ ノウ ショウ

この論文をさがす

抄録

It has been demonstrated that TJ-8007 (Tsumura-Zokumeito, A traditional Chinese medicine) has a protective effect against cerebral anoxia. This study was done to elucidate the protective mechanism of TJ-8007 against cerebral ischemia and anoxia. TJ-8007 (0.3 ?? 3.0g/kg, p.o.) inhibited the rise in the cumulative mortality rate after ligation of the bilateral carotid artery (BCA) in mice. TJ-8007 also significantly prolonged the survival time at the dose of 3.0 g/kg, p.o. However, TJ-8007 (1.0 or 3.0 g/kg, p.o.) did not affect the mean survival time after ligation of BCA in Mongolian gerbils and the gasping movement in a decapitated mouse head that served as a complete ischemic model. Ifenprodil (30 mg/kg, p.o.) also showed the protective effect only against ischemic death after ligation of BCA in mice. TJ-8007 (1.0 or 3.0 g/kg, p.o.) increased the vertebral blood flow, but showed no effect on the internal carotid blood flow in anesthetized dogs. These results suggest that the mechanism for the cerebral protective effect of TJ-8007 may be due to its ameliorating action on the cerebral circulation.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 93 (4), 255-260, 1989

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ