Studies on cardiovascular drugs
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- NAKANISHI Michio
- Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
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- IMAMURA Hiroshi
- Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
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- NAKAMURA Tadao
- Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.
Bibliographic Information
- Other Title
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- 心脈管系薬に関する研究
- シン ミャクカンケイヤク ニ カンスル ケンキュウ 9 イヌ ノ ジッケン フセイミャク ニ タイスル 1-tert-Butylamino-3- o- tetrahydro-furfuryloxy phenoxy -2-propanol hydrochloride Y-6124 ノ コウカ
- (9) Effect of 1-tert-butylamino-3-[o-(tetrahydrofurfuryloxy) phenoxy]-2-propanol hydrochloride (Y-6124) on the experimental arrhythmia in dogs
- 第9報イヌの実験不整脈に対する1-tert-Butylamino-3-[<i>o</i>-(tetrahydrofurfuryloxy) phenoxy]-2-propanol hydrochloride (Y-6124) の効果
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Abstract
1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride (Y-6124) inhibited at each dose of 50, 100 or 500μg/kg administered intravenously arrhythmia induced by rapid intravenous injection of 10μg/kg epinephrine in dogs anesthetized with sodium secobarbital, or arrhythmia induced by continuous infusion of 5μg/kg/ min epinephrine into the vein of a dog anesthetized with fluothane. Y-6124 and propranolol inhibited these epinephrine-induced arrhythmias at the almost the same dose as that of its β-blocking action. Y-6124 inhibited arrhythmia induced by continuous intravenous infusion of 5μg/kg/min ouabain in anesthetized dogs at a dose of 2.5 or 5mg/kg i. v., but did not change the lethal dose of ouabain in dogs. Propranolol inhibited arrhythmia and increased the lethal dose of ouabain in dogs. Y-6124 had a therapeutic effect on arrhythmia induced by intermittent and cumulative administration of ouabain at a dose of 2.5mg/kg i. v. or more. Potency was almost the same as that of propranolol.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 68 (2), 240-253, 1972
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204273085312
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- NII Article ID
- 130000757672
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE2cXkt1Sqt78%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 7624812
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- PubMed
- 4403394
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed