書誌事項
- タイトル別名
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- Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice
- カンポウ ホウザイ ニ ヨル トウニョウビョウ ビョウタイ マウス ノ ケット
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説明
The selective sensitivities to the blended Chinese traditional medicines (Kampo Hozai) applied for diabetes mellitus were pharmacologically studied utilizing the diabetic models: genetically diabetic KK-CAy mice and alloxan diabetic mice. The hypoglycemic response to sulfonylurea (tolbutamide) was observed in the KK-CAy mice as well as that to metformin, giving evidence which supported the difference of diabetic features between KK-CAy mice and alloxan diabetic mice. The hypoglycemic potencies of the blended medicines were determined in alloxan diabetics: Chikuyosekkoto>Byakkoka-Ninjinto≈Bakumondoto >> Hachimigan≈Ninjinto>Goreisan. A similar order of potency was shown in the fasted KK-CAy mice. In the nonfasted KK-CAy mice, Hachimigan selectively had the more marked hypoglycemic effect. In conclusion, it is compatible that the effects of Kampo Hozai may be classified into plural types of action mechanism by utilizing etiologically different diabetic models.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 83 (1), 1-10, 1984
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204273112832
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- NII論文ID
- 130000760912
- 10012762414
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- NII書誌ID
- AN00198335
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- DOI
- 10.1254/fpj.83.1
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- COI
- 1:STN:280:BiuC1czpslQ%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 2977144
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- PubMed
- 6425156
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可