Studies on biopharmacological activity of active vitamin D<SUB>3</SUB> analogues (VII)
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- KAWASHIMA Hiroyuki
- Teijin Institute for Bio-medical Research
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- OKAMIYA Yoshiaki
- Teijin Institute for Bio-medical Research
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- UENO Kohichi
- Teijin Institute for Bio-medical Research
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- KUROZUMI Seiji
- Teijin Institute for Bio-medical Research
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- HASHIMOTO Yoshinobu
- Teijin Institute for Bio-medical Research
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- MAKITA Tokutaro
- Teijin Institute for Bio-medical Research
Bibliographic Information
- Other Title
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- 活性型ビタミンD?S3?Tの生物活性 VII 1α‐ヒドロキシコレカルシフェロールのじん機能に与える影響
- カッセイガタ ビタミン D3 ノ セイブツ カッセイ ニカンスルケンキュウ 7
- 1α-Hydroxycholecalciferolの腎機能に与える影響
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Abstract
In male Wistar rats, 1α-HCC and 1α, 25-DHCC induced diuretic effects in doses of 2.5 and 25μg/kg p.o., while no such effects of 1α-HCC were seen with a dose of 0.25 μg/kg p.o. Effect of 1α-HCC appeared later than that of 1α, 25-DHCC, but at 24 hr, the difference disappeared. Similar results were obtained with urinary concentrations of calcium (increase) and phosphorus (decrease). Glomerular filtration rate (GFR) and tubular reabsorption of phosphate (TRP) were remarkably elevated by 1α, 25-DHCC, and effects of 1α-HCC were rather weak and apparently not dose dependent. In light of these results and the finding that there was no difference between the effects of 1α-HCC and 1α, 25-DHCC on serum calcium and phosphorus at 24 hr, the mechanism of action of these sterols on the renal function seems to differ. In male Beagle dogs, 0.25 μg/kg/day p.o. of 1α-HCC or 1α, 25-DHCC induced a severe hypercalcemia and GFR was decreased in the 1α, 25-DHCC treated group. A gradual recovery occurred with cessation of the administration. Thus decrease in GFR was considered to be due to calcification of the kidney.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 75 (6), 617-631, 1979
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204273190016
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- NII Article ID
- 130000759120
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL3cXmvFCksA%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 2095478
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- PubMed
- 540887
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed