Ｃａｒｐｅｒｉｔｉｄｅ（α‐ｈｕｍａｎ　ａｔｒｉａｌ　ｎａｔｒｉｕｒｅｔｉｃ　ｐｅｐｔｉｄｅ）の循環器系に対する作用

DOI Web Site PubMed 被引用文献7件

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タイトル別名
  • Effect of carperitide (.ALPHA.-human atrial natriuretic polypeptide) on the cardiovascular system in experimental animals.
  • Carperitide アルファ human atrial natriuret

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The cardiovascular and diuretic actions of carperitide were studied in experimental animals. Carperitide relaxed various canine arteries and veins that were contracted by high K+ or norepinephrine. Carperitide stimulated particulate guanylate cyclase from rat thoracic aortas. Carperitide had almost no effect on coronary perfusion pressure or heart rate, but caused a slight decrease in contractile force in isolated guinea pig hearts. Carperitide tended to decrease isoproterenol-induced renin release from isolated rat kidney slices and elicited decreases in angiotensin II-induced aldosterone release from bovine zona glomerulosa cells. Intravenous injection of carperitide elicited decreases in arterial blood pressure and total peripheral resistance in the anesthetized and conscious dogs. Carperitide also elicited transient increases in cardiac output and coronary blood flow followed by slight decreases in them. Intravenous infusion of carperitide elicited decreases in pulmonary capillary wedge pressure, pulmonary pressure and right atrial pressure in association with elevating plasma carperitide (ANP like immuno-reactivity) level in dogs with heart failure induced by coronary artery occlusion and saline loading. These results suggest that carperitide decreases both preload and afterload and can improve the untoward hemodynamic alterations in animals with acute experimental heart failure.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 101 (5), 309-325, 1993

    公益社団法人 日本薬理学会

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