ジラゼプの正常時脳血流および脳虚血後の再かん流障害に対する作用

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タイトル別名
  • Effects of dilazep on cerebral blood flow under normal conditions and recirculation impairment after cerebral ischemia
  • Dilazep ノ セイジョウジ ノウ ケツリュウ オヨビ ノウ キョケツゴ

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説明

Regional cerebral blood flow (r-CBF) in anesthetized dogs was measured by the H2 clearance method. Cerebral ischemia was induced by permanent ligation of bilateral vertebral arteries (VA) and a 10 min occlusion of bilateral common carotid arteries (CCA). Under normal conditions, dilazep (100 and 300 μg/kg i.v.) increased r-CBF dose-dependently without affecting arterial PO2, PCO2 and pH. r-CBF was reduced by 40% during cerebral ischemia. Relative r-CBF rates, as compared with pre-ischemic rates, were 85%, 80%, 77% and 75% at 30, 60, 90 and 120 min after cerebral ischemia, respectively, indicating development of recirculation impairment. Dilazep (100 and 300 μg/kg i.v. 30 min before CCA occlusion) did not affect r-CBF reduction during the state of cerebral ischemia, whereas it prevented re-circulation impairment after cerebral ischemia. Papaverine (300 μg/kg i.v. 30 min before CCA occlusion) exerted similar effects. These results suggest that dilazep is a potentially effective drug for treating cerebrovascular disorders.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 77 (2), 205-211, 1981

    公益社団法人 日本薬理学会

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