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- 比佐 博彰
- 東北大学大学院薬学研究科薬理学分野
書誌事項
- タイトル別名
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- Experimental pharmacology of the in vivo kidney. Renal actions of cAMP-related drugs.
- セイタイイジン ノ ジッケン ヤクリ cAMP カンレンヤク ノ ジンサヨウ
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抄録
The kidney plays a pivotal role in cardiovascular homeostasis through control of extracellular fluid volume, the mechanisms of which have been studied in detail at both cellular and molecular levels in each portion of the kidney. Renal clearance experiments in vivo are useful for analyzing renal functions as the integrated system of vascular, glomerular and tubular components. Physiological responses and drug effects within the kidney can be more clearly analyzed by measuring renal release of endogenous substances and by applying intrarenal arterial drug administration. For example, our recent studies in anesthetized dogs revealed the participation of phosphodiesterase IV in regulation of renal cAMP level and the influences by changes in renal cAMP level on renal hemodynamics, glomerular filtration and tubular reabsorption. The in vivo experiments also allow us to evaluate a sequence of events in the neural control of renal functions. We observed that an adenylate cyclase activator counteracted hypofiltration to attenuate antinatriuresis during sympathetic activation without inhibiting neurotransmitter release. The experiments in the in vivo kidney, although they provide only indirect information on intracellular events, are necessary for understanding the total renal functions and could thereby contribute to physiology and pharmacology of the cardiovascular system.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 115 (2), 89-98, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204273330176
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- NII論文ID
- 10005705567
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DC%2BD3cXpsVChug%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 4974750
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- PubMed
- 10876795
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可