新規カルシウムきっ抗薬ｐｒａｎｉｄｉｐｉｎｅ（ＯＰＣ‐１３３４０）の摘出ブタ冠動脈の収縮および急性心筋虚血モデルに対する作用

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • Effects of pranidipine (OPC-13340), a novel 1,4-dihydropyridine derivative Ca-antagonist, on isolated porcine coronary contraction and acute myocardial ischemia in the pig.
  • シンキ カルシウム キッコウヤク pranidipine OPC-13340

この論文をさがす

説明

Pranidipine (OPC-13340) is a novel, potent and long-acting 1, 4-dihydropyridine derivative Ca-antagonist being developed for clinical use as an antihypertensive and antianginal drug. Pranidipine at concentrations of 10-9 ?? 10-6 M suppressed the contraction induced by serotonin (10-8 ?? 10-5 M) or histamine (10-8 ?? 10-4 M) in isolated porcine coronary arteries in a non-competitive and concentration-dependent manner. The potency of this effect of pranidipine was almost similar to that of nifedipine. In anesthetized open-chest pigs with coronary artery occlusion, pranidipine at a dose of 10 μg/kg, i.v. lowered blood pressure and increased heart rate, peak dP/dt and % segment shortening of the non-ischemic zone before occlusion. Pranidipine inhibited the ST elevation of the electrocardiogram and the increase in left ventricular end-diastolic pressure during ischemia. These results suggest that pranidipine might relieve symptoms via inhibition of coronary spasm and reduce myocardial ischemia due to reduction of both preload (left ventricular end-diastolic pressure) and afterload (blood pressure).

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 103 (3), 101-109, 1994

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ