Basal studies on the model of circular excisional wounds made on the dorsal skin of rats treated with hydrocortisone.

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  • Ｈｙｄｒｏｃｏｒｔｉｓｏｎｅ負荷ラット背部皮膚円形切除創モデルに関する基礎的検討
  • Hydrocortisone フカ ラット ハイブ ヒフ エンケイ セツジョ

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This study was performed to establish a circular excisional wound model treated with hydrocortisone (HC-P) and to estimate the following parameters in this model: wound area, hydroxyproline (Hyp) content, histological characteristics and microscopical measurements of histological sections. HC-P inhibited the reduction of wound area, the increase in Hyp content and proliferation of granulation tissue in a dose-dependent manner. The application of ZnO ointment significantly accelerated the reduction of wound area and the increased Hyp content in rats treated with HC-P. From these results, we concluded that this experimental model is useful for the objective evaluation of the efficacy of drugs that promote wound healing.

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