Limitation of experimental infarct size by levocarnitine chloride(LC-80), a new mitochondrial function-reactivating agent.
-
- FUJISAWA Shigeki
- Development Department, Earth Chemical Co. Ltd.
-
- TACHIKAWA Nobunari
- Development Department, Earth Chemical Co. Ltd.
-
- MURAKAMI Eiji
- Development Department, Earth Chemical Co. Ltd.
-
- MASUDA Masashi
- Development Department, Earth Chemical Co. Ltd.
-
- MIZUTANI Sadafumi
- Development Department, Earth Chemical Co. Ltd.
-
- MIZUTANI Mari
- Development Department, Earth Chemical Co. Ltd.
-
- HIROSE Yukihiro
- Development Department, Earth Chemical Co. Ltd.
-
- YAMADA Hiroaki
- Development Department, Earth Chemical Co. Ltd.
-
- FUJITA Kazuhiko
- Development Department, Earth Chemical Co. Ltd.
-
- HASEBE Tokuko
- Development Department, Earth Chemical Co. Ltd.
-
- HAYASHI Hiromi
- Development Department, Earth Chemical Co. Ltd.
-
- YASO Yuriko
- Development Department, Earth Chemical Co. Ltd.
-
- HIRONAKA Yutaka
- Development Department, Earth Chemical Co. Ltd.
-
- KAWAGUCHI Naomasa
- Department of Pathology, College of Biomedical Technology, Osaka University
-
- ONISHI Shunzo
- Department of Pathology, College of Biomedical Technology, Osaka University
Bibliographic Information
- Other Title
-
- ミトコンドリア機能賦活作用を有する塩化レボカルニチン(LC‐80)の実験的急性心筋梗塞に対する作用
- ミトコンドリア キノウ フカツ サヨウ オ ユウスル エンカ レボカルニチン
Search this article
Description
The effect of LC-80 on infarct size induced by 6 hr coronary occlusion was studied in anesthetized dogs. LC-80 at a dose of 100 mg/kg, i.v. was injected 5 min after coronary occlusion and then infused at a rate of 50 mg/kg, i.v./hr until the heart was excised. The two risk areas were determined both by injecting a fluorescent dye (Thioflavin S) into the left atrium (in vivo) and by perfusing the non-occluded coronary bed with Monastral Blue (in vitro). The infarct size was determined by topographically tracing the area of myocardium unstained by triphenyltetrazolium chloride. Four zones such as Zone 1 (normal tissue), Zone 2 (tissue characterized by collateral blood flow), Zone 3a (tissue developing necrosis), Zone 3b (necrotic tissue) were delimitated. As a result, (1) LC-80 significantly diminished the incidence of ventricular arrhythmias. (2) LC-80 significantly inhibited the decrease in myocardial free carnitine level in Zone 2 and Zone 3b. (3) LC-80 significantly reduced the infarct size expressed as a percentage of the risk area and increased the size of Zone 2. (4) In the electron microscopic findings, LC-80 showed lesser morphological changes such as swollen mitochondria and intracellular and extracellular edema, especially in Zone 2. (5) LC-80 may be useful for inhibiting the evolution of myocardial ischemic cell death both by the protection of ischemic myocardium and presumably by the increase in the collateral blood flow.
Journal
-
- Folia Pharmacologica Japonica
-
Folia Pharmacologica Japonica 96 (5), 227-242, 1990
The Japanese Pharmacological Society
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001204273594368
-
- NII Article ID
- 130000758989
-
- NII Book ID
- AN00198335
-
- ISSN
- 13478397
- 00155691
-
- NDL BIB ID
- 3698018
-
- PubMed
- 2279712
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed