Ｘ線照射により惹起したマウスの造精機能障害に及ぼすＭｅｃｏｂａｌａｍｉｎの効果

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タイトル別名
  • Effects of mecobalamin on testicular dysfunction induced by X-ray irradiation in mice.
  • Xセン ショウシャ ニ ヨリ ジャッキシタ マウス ノ ゾウセイ キノウ ショ

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Experimental testicular dysfunction were produced by X-ray irradiation to the testes in mice. Mecobalamin (CH3-B12) was orally administered at a daily dose of 0.01, 0.1 or 1 mg/kg six times a week for 8 weeks from the next day after the irradiation. The control mice received physiological saline in the same manner. On 4th and 6th-week after the irradiation, the weights of testes and epididymides were decreased, although those of the body and accessory sex glands (seminal vesicle, coagulating gland and prostate) were nearly equal to those of non-irradiated mice. At the same time, the diameter of seminiferous tubules decreased and sperm parameters (sperm count, sperm motility and sperm abnormality) deteriorated. When CH3-B12 (1 mg/kg) was administered, the diameter of seminiferous tubules increased and sperm parameters improved as compared to those of the control. The results indicate that CH3-B12 improved the experimental testicular dysfunction in mice induced by the irradiation. These results suggest that CH3-B12 might accelerate testicular function.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 98 (6), 483-490, 1991

    公益社団法人 日本薬理学会

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