BaicalinおよびBaicaleinの薬理作用 (第1報)

DOI Web Site PubMed 被引用文献5件

書誌事項

タイトル別名
  • Pharmacological actions of baicalin and baicalein
  • ノウドウテキ アナフィラキシー ハンノウ ニ オヨボス エイキョウ
  • (Report 1) On the active anaphylaxis
  • ―能動的アナフィラキシー反応に及ぼす影響―

この論文をさがす

説明

In the Chinese medicine, Scutellaria baicalensis GEORG has been used as a remedy for some of allergic diseases. Therefore, the authors investigated the effects of baicalin and baicalein, components of the drug, on active anaphylactic reaction in guinea pig, and the results obtained were compared with those of rutin, methylhesperidin and quercetin. 1) By the administration of baicalin, the onset of preconvulsion caused by the antigen-aerosol in actively sensitized guinea pig was delayed about 3 times in contrast to the control, and the effect of baicalin was more potent than that of rutin. 2) Baicalin and baicalein inhibited Schulz-Dale reaction in isolated ileum, and the intensity of inhibition was following order; in glycoside, baicalin>rutin>methylhesperidin, and in aglycon, baicalein>quercetin. Futhermore, the effect of aglycone was more potent than that of each glycoside. 3) As the antigen was added to the organ bath which placed sensitized and non-sensitized ileum, sensitized ileum strongly contracted followed by contraction of non-sensitized one. In this condition, baicalin decreased the contraction of non-sensitized ileum, while baicalein strongly decreased those of both ones. 4) Baicalin and baicalein slightly showed antihistaminic and anticholinergic effects on ileum of guinea pig. 5) The antigen-antibody combination was not affected by baicalin or baicalein in ring precipitation test. 6) The release of histamine and SRS-A from sinsitized guinea pig lung which perfused with antigen were decreased by baicalin, and the decreasing activity was more remarkable than that of rutin. 7) Baicalin and baicalein inhibited the anaphylactic release of histamine and SRS-A from chopped tissue of guinea pig lung. There was not much difference between the inhibitory activities of them in a equal molar concentration. However, they neither affected the destruction of mediator released nor inhibited contraction of ileum by mediator. The inhibitory action of baicalein on release of mediator was not affected by the addition of Ca++, but decreased by cysteine.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 66 (2), 194-213, 1970

    公益社団法人 日本薬理学会

被引用文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ