Biological activity of lα-hydroxycholecalciferol (1). Effect on intestine and bone in rats.

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  • 活性型ビタミンＤ３　Ｉ　　１α‐ヒドロキシコレカルシフェロールの主作用
  • カッセイガタ ビタミン D3 ニカンスルケンキュウ 1 1アルファ Hydro

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Abstract

Biological activity of 1α-hydroxycholecalciferol was studied in rats. 1α-Hydroxycholecalciferol was found to be more potent and rapidly active than vitamin D in stimulating intestinal calcium transport and calcium mobilization from bone both in normal and vitamin D deficient rats. 1α-Hydroxycholecalciferol was also active in nephrectomized and/or thyroparathyroidectomized rats both in intestine and bone. Although it is well known that 1α-hydroxycholecalciferol is metabolized to lα, 25-dihydroxycholecalciferol in the liver, there is the possibility that the former is active without further metabolism. In rats in which hepatitis was induced by CCl4, 1α-hydroxycholecalciferol was active both in the intestine and in the bone, while it was inactive in hepatectomized rats. These data clearly demonstrate that 1α-hydroxycholecalciferol is not active by itself and must be metabolized in the liver. This idea also shows the lag time in response of rats to 1α-hydroxycholecalciferol as compared with that of 1α, 25-dihydroxycholecalciferol. It was also demonstrated that 1α-hydroxycholecalciferol has more potent antirachitic activity than vitamin D and does not lose its activity with chronic oral administration. In view of these findings, 1α-hydroxycholecalciferol appears to have a good potential for clinical application in cases of renal failure and metabolic bone diseases.

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