The effect of quinine on methamphetamine-induced anorexia in rats
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- SUZUKI Tsutomu
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- FANCHIANG Horng Jen
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- ABE Youichi
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- OHTANI Koukichi
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- YANAURA Saizo
- Department of Pharmacology, School of Pharmacy, Hoshi University
Bibliographic Information
- Other Title
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- Methamphetamine誘発Anorexiaに対するQuinineの効果
- Methamphetamine ユウハツ Anorexia ニ タイスル Qu
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Abstract
Two experiments were done to examine the effect of quinine (Q) on methamphetamine (MA)-induced anorexia in rats. They were fasted throughout (water allowed ad libitum) except for a period of 6 hr (10:00-16:00) every day when powder food was offered. In the first experiment, the drug-admixed food (DAF) method was used for testing the effect of MA in combination with Q and MA alone on food consumption and the growth curve. However, the possibility exists that MA plus Q-admixed food increases the aversive reaction. Considering this possibility, we used the injection method in the second experiment. Rats received Qorally by a stomach tube and MA by subcutaneous injection. The injection was made 30 min before the presentation of food. In the DAF method, food consumption and weight of the MA and MA plus Q groups were inhibited. The inhibitions of the MA plus Q group were more potent than that of the MA group. In the injection method, the inhibitions of food consumption and growth curve in the MA plus Q group were significantly different from that of the MA group and were dose-dependent on MA. Tolerance to MA, as index of MA- induced anorexia, developed rapidly in the injection method, while tolerance to MA in the DAF method did not develop during the experiment. These results indicate that Q can markedly potentiate MA- induced anorexia.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 82 (2), 149-157, 1983
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204273797888
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- NII Article ID
- 130000760586
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL3sXltFGmurc%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 2638620
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- PubMed
- 6582023
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed