Cardiotonic effects of proscillaridin A
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- HORII Daijirou
- Kowa Tokyo Research Laboratories, Kowa Co. Ltd.
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- SANO Nobuyuki
- Kowa Tokyo Research Laboratories, Kowa Co. Ltd.
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- NAKAMURA Masaki
- Kowa Tokyo Research Laboratories, Kowa Co. Ltd.
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- MORI Motokuni
- Kowa Tokyo Research Laboratories, Kowa Co. Ltd.
Bibliographic Information
- Other Title
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- Proscillaridin Aの強心作用について
- Proscillaridin A ノ キョウシン サヨウ ニ ツイテ
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Abstract
Cardiotonic effect of proscillaridin A, cardiac glycoside derived from a squill, was tested in some methods.<br> 1. Lethal doses (Hatcher doses) of proscillaridin A were 0.142mg/kg in cats, 0.152mg/kg in dogs, and 0.484mg/kg in rabbits, whereas the dose of g-strophanthin was 0.104mg/kg in cats.<br> 2. 3.16×10-8 Molar concentration of proscillaridin A showed a persistent 60% increase of contractile force in cat papillary muscle preparation.<br> 3. Contractile force of left ventricular muscle showed 9% increase after the second administration (total proscillaridin A 0.04mg/kg) in phenobarbital induced myocardial depression.<br> 4. The ratio between the maximum rate of development isometric tension (dp/dt) and a constant fraction of the integrated isometric tension developed (IIT) showed 12% increase after the second administration of proscillaridin A.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 69 (1), 31-39, 1973
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204275685376
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- NII Article ID
- 130000757810
- 10005527133
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE2MXotVCqtw%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 7624872
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- PubMed
- 4737525
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed