カプセル剤のラット胃内投与法の考案ならびに本法を用いる薬効評価について

DOI Web Site PubMed

書誌事項

タイトル別名
  • A device for the drug-capsule administration into the rat stomach and its pharmacological application
  • カプセルザイ ノ ラット イナイ トウヨホウ ノ コウサツ ナラビニ ホンポウ

この論文をさがす

説明

To assess the absorption of drugs given in capsule form to rats, the method of administration was studied using gastric-cannulated rats. The body weight of these rats remained the same as even when given casein hydro-Iysate and vitamins in addition to the usual chow diet. Indomethacin (IM) capsule (2mg/capsule) was given and the plasma concentration and anti-inflammatory action of IM were studied. The maximum plasma concentration was seen at 2hr after administration of one capsule. The carrageenin-induced edema of rat hind paw was inhibited with the ingestion of only one capsule. In addition, the time course of the plasma concentration of IM correlated with that of the inhibitory effect of carrageenin-induced edema. In the case of administration of a barium sulfate capsule to the cannulated rats, the transfer of the barium sulfate was clearly observed on the X-rays. Our findings suggest that this approach to the estimation of drugs is feasible, at least in experimental animals.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 78 (5-6), 393-401, 1981

    公益社団法人 日本薬理学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ