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- KITAGAWA Junichi
- Departments of Oral Surgery, Osaka University Dental School
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- IWATSUBO Katsuya
- Departments of Pharmacology, Osaka University Dental School
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- SHIGENAGA Yoshio
- Departments of Anatomy, Osaka University Dental School
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- INOKI Reizo
- Departments of Pharmacology, Osaka University Dental School
Bibliographic Information
- Other Title
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- EnfluranとHalothaneの薬理作用比較
- Enflurane ト Halothane ノ ヤクリ サヨウ ヒカク
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Abstract
General pharmacological properties of enflurane (E) and halothane (H) were investigated. Maximum bloodconcentrations of both drugs reached 30min after inhalation. E showed lower maximum blood concentration, initial velocity of uptake and shorter half life than H. Neither drug had any effect on neuromuscular junction, but E increased N-M effect of succinylcholine. Both drugs decreased tension of uterine and intestine muscles. Poly- and monosynaptic reflexes were inhibited more by H. ED50's of E and H for righting reflex were 1.25 and 1.40%, respectively. Tonic and clonic convulsions and death induced by electric shock were inhibited more by E. Almost equal anticonvulsive potency was observed for chemoshocks. Death due to electric and chemoshock was remarkably inhibited by both drugs. Spontaneous EEG was altered in a different manner, although flattened with spikes at 4% concentration of both drugs. E altered rhythmicity of recruiting response and both drugs inhibited this response. H inhibited more remarkably the augmenting response and E inhibited the arousal response. E increased negative potentials of the primary response evoked by sensory stimulation, while H decreased these potentials. Both drugs completely inhibited the secondary response.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 72 (1-2), 211-227, 1976
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204275968128
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- NII Article ID
- 130000758378
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 1703341
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- PubMed
- 987967
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed