Elevation of Cystathionine .GAMMA.-lyase Activity in the Serum of Rats Treated with a Single Dose of Carbon Tetrachloride.
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- TAGUCHI Tetsuya
- Department of Environmental and Occupational Health, Kochi Medical School
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- AWATA Shiro
- Department of Nutritional Biochemistry, Kochi Gakuen College
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- NISHIOKA Michiko
- Department of Biochemistry, Kochi State Women's University
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- ARAKAWA Yukiko
- Department of Biochemistry, Kochi State Women's University
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- SHIRAISHI Noriyuki
- Department of Environmental and Occupational Health, Kochi Medical School
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- RYU Shuhei
- Department of Environmental and Occupational Health, Kochi Medical School
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- KUMAZAWA Hideo
- Department of Parasitology, Kochi Medical School
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- TAKANO Yasuo
- Department of Anatomy, Kochi Medical School
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- NAKAYAMA Kazuko
- Department of Nutritional Biochemistry, Kochi Gakuen College
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- YAGYU Kenichi
- Medical Research Laboratory, Kochi Medical School
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- KAWAMURA Mami
- Department of Biochemistry, Kochi State Women's University
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- SATO Atsushi
- Department of Biochemistry, Kochi State Women's University
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説明
Cystathionine γ-lyase activity in the sera of rats subjected to experimental hepatotoxicity after intraperitoneal administration of carbon tetrachloride (CCl4) was measured and compared with activities of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), which have been clinically used for detecting liver damage. In the experimental subjects, serum levels of cystathionine γ-lyase showed a similar behavior to GOT and GPT, increasing markedly with respect to the controls after administration of CCl4 and reaching a maximum at 24 hours. No such cystathionine γ-lyase activity was detected immunochemically in the control subjects. These data suggest that measurement of serum cystathionine γ-lyase activity could be used as a sensitive and specific marker of hepatic cytolysis.
収録刊行物
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- Ｉｎｄｕｓｔｒｉａｌ ｈｅａｌｔｈ
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Ｉｎｄｕｓｔｒｉａｌ ｈｅａｌｔｈ 33 (4), 199-205, 1995
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所