Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

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  • PELCLOVA Daniela
    Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • FENCLOVA Zdenka
    Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • VLCKOVA Stepanka
    Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • LEBEDOVA Jindriska
    Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Department of Occupational Medicine of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • SYSLOVA Kamila
    Institute of Chemical Technology Institute of Chemical Technology, AS CR, v. v. i., Czech Republic
  • PECHA Ondrej
    Institute of Informatics of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Institute of Informatics of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • BELACEK Jaromir
    Institute of Informatics of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital Institute of Informatics of the 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic
  • NAVRATIL Tomas
    J. Heyrovský Institute of Physical Chemistry J. Heyrovský Institute of Physical Chemistry, AS CR, v. v. i., Czech Republic
  • KUZMA Marek
    Institute of Microbiology Institute of Microbiology, AS CR, v. v. i., Czech Republic
  • KACER Petr
    Institute of Chemical Technology Institute of Chemical Technology, AS CR, v. v. i., Czech Republic

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説明

Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2–t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0–s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (–0.313, p<0.05) and TLCO/Hb (–0.307, p<0.05), and LT C4 with TLC (–0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.<br>

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