Toluene A1ters Mu-Opioid Receptor Expression in the Rat Brainstem

  • SARACIBAR Gonzalo
    Department of Physiology, School of Pharmacy, University of the Basque Country
  • HERNANDEZ Maria Luisa
    Department of Physiology, School of Pharmacy, University of the Basque Country
  • ECHEVARRIA Enrique
    Department of Physiology, School of Pharmacy, University of the Basque Country
  • BARBERO Ismael
    Department of Physiology, School of Pharmacy, University of the Basque Country
  • GUTIERREZ Arantza
    Department of Physiology, School of Pharmacy, University of the Basque Country
  • CASIS Oscar
    Department of Physiology, School of Pharmacy, University of the Basque Country

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  • Toluene Alters Mu-Opioid Receptor Expression in the Rat Brainstem.

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Toluene is an ototoxic organic solvent widely used in industry and could be a cause of sleep apnea. Acute toluene administration in rats induces an increase in the number of neural cells immunostained for mu-opioid receptors in several brainstem nuclei, such as the inferior colliculus, dorsal and lateral periaqueductal gray and dorsal raphe, without changes in the superior colliculus and the interpeduncular and lateral reticular nuclei. These data suggest that mu-opioid receptors could be involved in toluene-induced neurotoxic effects on the physiological regulation of breathing during sleep, and auditive function.

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