Effect of Platinum Coordination Complex (PtCx) on Citrate Uptake by Rat Renal Brush Border Membrane Vesicles (BBMV): Cisplatin-Intoxicated Rats.
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- SATO Kazuhiro
- Department of Environmental Health, Fukui Medical University
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- KUSAKA Yukinori
- Department of Environmental Health, Fukui Medical University
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- CHIBA Yukio
- Department of Surgery, Fukui Medical University
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- OKADA Kenichiro
- Department of Urology, School of Medicine, Fukui Medical University
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Abstract
Platinosis with severe dermatitis and/or asthma is broadly defined as the effects of soluble platinum salts on people exposed to them occupationally. Platinum coordination complexes are widely used in the treatment of a variety of solid tumors. However, the clinical use of cisplatin, the most useful agent, is limited by the development of nephrotoxicity. Thus, an accidental exposure to soluble platinum at a high dose in platinum refineries and pharmaceutical factories could induce occupational nephrotoxicity. Urinary citrate is freely filtered at the glomerulus, and its reabsorption in the proximal tubule is the major determinant of the rate of renal excretion. In our previous studies, we found that the preincubation of rat renal brush border membrane vesicles (BBMV) with cisplatin and carboplatin, a second-generation platinum coordination complex, significantly inhibited the citrate uptake compared with that of the control BBMV. In this study, we performed in vivo expriments in cisplatin-intoxicated rats to elucidate the toxic mechanism of cisplatin. And our results showed that the citrate uptake was significantly inhibited in cisplatin-intoxicated rats at 1 min compared with that of control rats.
Journal
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- Industrial Health
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Industrial Health 39 (4), 317-321, 2001
National Institute of Occupational Safety and Health
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Details 詳細情報について
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- CRID
- 1390001204279974272
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- NII Article ID
- 130003551012
- 120003002615
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- NII Book ID
- AA00672955
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- COI
- 1:CAS:528:DC%2BD3MXot1Sqs74%3D
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- ISSN
- 18808026
- 00198366
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- NDL BIB ID
- 5996622
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- PubMed
- 11758994
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed